Effect of age and disease duration on parkinsonian motor scores under levodopa therapy
Identifieur interne : 000770 ( Main/Corpus ); précédent : 000769; suivant : 000771Effect of age and disease duration on parkinsonian motor scores under levodopa therapy
Auteurs : G. Ransmayr ; G. Künig ; M. Neubauer ; M. Wagner ; M. FalkSource :
- Journal of Neural Transmission - Parkinson's Disease and Dementia Section [ 0936-3076 ] ; 1995-06-01.
Abstract
Summary: One hundred and fifty patients suffering from Parkinson's disease were analysed for the expression of the motor symptoms during optimum response to levodopa therapy (subscale III of the Unified Parkinson's Disease Rating Scale). Patients were grouped according to age (≤64, 65–74, ≥75 years). Disease duration and daily levodopa dosage were similar in the three groups. Pooled residual scores for posture and gait impairment (PGI), tremor (T), rigidity (R) and distal motor impairment (DMI; hand and foot movements) increased with age (Kruskal-Wallis ANOVA). The parkinsonian scores were significantly higher than the scores of 150 age-matched normal controls (Mann-Whitney U test). The differences between the patients' scores and the scores of the age-matched controls increased with age. In spite of a significant increase in the daily levodopa dosage with disease duration (linear regression), PGI aggravated age-dependently, and DMI age-independently with symptom duration (Spearman rank correlation). In contrast, T and R did not increase with disease duration.
Url:
DOI: 10.1007/BF02259659
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ISTEX:47B5F26E14120A455DB5CB0281B7FABA1A4F766ELe document en format XML
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Patients were grouped according to age (≤64, 65–74, ≥75 years). Disease duration and daily levodopa dosage were similar in the three groups. Pooled residual scores for posture and gait impairment (PGI), tremor (T), rigidity (R) and distal motor impairment (DMI; hand and foot movements) increased with age (Kruskal-Wallis ANOVA). The parkinsonian scores were significantly higher than the scores of 150 age-matched normal controls (Mann-Whitney U test). The differences between the patients' scores and the scores of the age-matched controls increased with age. In spite of a significant increase in the daily levodopa dosage with disease duration (linear regression), PGI aggravated age-dependently, and DMI age-independently with symptom duration (Spearman rank correlation). In contrast, T and R did not increase with disease duration.</Para></Abstract><KeywordGroup Language="En"><Heading>Keywords</Heading><Keyword>Parkinson's disease</Keyword><Keyword>motor scores</Keyword><Keyword>age</Keyword><Keyword>disease duration</Keyword><Keyword>levodopa</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effect of age and disease duration on parkinsonian motor scores under levodopa therapy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effect of age and disease duration on parkinsonian motor scores under levodopa therapy</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">G.</namePart><namePart type="family">Ransmayr</namePart><affiliation>Department of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Künig</namePart><affiliation>Department of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Neubauer</namePart><affiliation>Department of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Wagner</namePart><affiliation>Department of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Falk</namePart><affiliation>Department of Biostatistics, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Vienna</placeTerm></place><dateCreated encoding="w3cdtf">1994-07-26</dateCreated><dateIssued encoding="w3cdtf">1995-06-01</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: One hundred and fifty patients suffering from Parkinson's disease were analysed for the expression of the motor symptoms during optimum response to levodopa therapy (subscale III of the Unified Parkinson's Disease Rating Scale). Patients were grouped according to age (≤64, 65–74, ≥75 years). Disease duration and daily levodopa dosage were similar in the three groups. Pooled residual scores for posture and gait impairment (PGI), tremor (T), rigidity (R) and distal motor impairment (DMI; hand and foot movements) increased with age (Kruskal-Wallis ANOVA). The parkinsonian scores were significantly higher than the scores of 150 age-matched normal controls (Mann-Whitney U test). The differences between the patients' scores and the scores of the age-matched controls increased with age. In spite of a significant increase in the daily levodopa dosage with disease duration (linear regression), PGI aggravated age-dependently, and DMI age-independently with symptom duration (Spearman rank correlation). In contrast, T and R did not increase with disease duration.</abstract><note>Full Papers</note><relatedItem type="host"><titleInfo><title>Journal of Neural Transmission - Parkinson's Disease and Dementia Section</title></titleInfo><titleInfo type="abbreviated"><title>J Neural Transm Gen Sect</title></titleInfo><genre type="Journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1995-06-01</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Pharmacology/Toxicology</topic><topic>Psychiatry</topic><topic>Neurology</topic></subject><identifier type="ISSN">0936-3076</identifier><identifier type="eISSN">1435-1463</identifier><identifier type="JournalID">722</identifier><identifier type="IssueArticleCount">16</identifier><identifier type="VolumeIssueCount">3</identifier><part><date>1995</date><detail type="volume"><number>9</number><caption>vol.</caption></detail><detail type="issue"><number>2-3</number><caption>no.</caption></detail><extent unit="pages"><start>177</start><end>188</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1995</recordOrigin></recordInfo></relatedItem><identifier type="istex">47B5F26E14120A455DB5CB0281B7FABA1A4F766E</identifier><identifier type="DOI">10.1007/BF02259659</identifier><identifier type="ArticleID">Art8</identifier><identifier type="ArticleID">BF02259659</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1995</recordOrigin></recordInfo></mods></metadata><enrichments><istex:refBibTEI uri="https://api.istex.fr/document/47B5F26E14120A455DB5CB0281B7FABA1A4F766E/enrichments/refBib"><teiHeader></teiHeader><text><front></front><body></body><back><listBibl><biblStruct xml:id="b0"><analytic><title level="a" type="main">Reduced D2 dopamine and muscarinic cholinergic receptor densities in caudate specimens from fluctuating parkinsonian patients</title><author><persName><forename type="first">Je</forename><surname>Ahlskog</surname></persName></author><author><persName><forename type="first">E</forename><surname>Richelson</surname></persName></author><author><persName><forename type="first">A</forename><surname>Nelson</surname></persName></author><author><persName><forename type="first">P</forename><forename type="middle">J</forename><surname>Kelly</surname></persName></author><author><persName><forename type="first">H</forename><surname>Okazaki</surname></persName></author><author><persName><forename type="first">Gm</forename><surname>Tyce</surname></persName></author><author><persName><forename type="first">Ja</forename><surname>Van Heerden</surname></persName></author><author><persName><forename type="first">Sl</forename><surname>Stoddard</surname></persName></author><author><persName><forename type="first">Sw</forename><surname>Carmichael</surname></persName></author></analytic><monogr><title level="j">Ann Neurol</title><imprint><biblScope unit="volume">30</biblScope><biblScope unit="page" from="185" to="191"></biblScope><date type="published" when="1991"></date></imprint></monogr></biblStruct><biblStruct xml:id="b1"><analytic><title level="a" type="main">Diagnostic and statistical manual of mental disorders, 3rd ed-revised. 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